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COT Rapid Test Cassette - WB/S/P

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COT Rapid Test Cassette - WB/S/P JusChek Drug of Abuse Rapid Test


¡¾SUMMARY¡¿
Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays. In a 24-hour whole blood or serum or plasma, approximately 5% of a nicotine dose is excreted as unchanged drug with 10% as cotinine and 35% as hydroxy cotinine; the concentrations of other metabolites are believed to account for less than 5%.1 While cotinineis thought to be an inactive metabolite, it’s elimination profile is more stable than that of nicotine which is largely whole blood whole blood/serum/plasma pH dependent. As a result, cotinine is considered a good biological marker for determining nicotine use. The plasma half-life of nicotine is approximately 60 minutes following inhalation or parenteral administration.2 Nicotine and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in whole blood or serum or plasma at a cutoff level of 10ng/ml or 100ng/ml is expected to be up to 2-3 days after nicotine use.
The COT Rapid Test Cassette (whole blood/serum/plasma) is a rapid whole blood/serum/plasma-screening test that can be performed without the use of an instrument. The test utilizes a monoclonal antibody to selectively detect elevated levels of Cotinine in whole blood or serum or plasma. The COT Rapid Test Cassette (whole blood/serum/plasma) yields a positive result when the Cotinine in whole blood or serum or plasma exceeds the cut-off level (10ng/ml or 100ng/ml).
 
 
¡¾DIRECTIONS FOR USE¡¿
Allow the test, specimen, buffer and/or controls to reach room temperature (15-30°C) prior to testing.
For serum or plasma specimen:
1. Bring the pouch to room temperature (15-30¡æ) before opening it. Remove the cassette from the sealed pouch and use it within one hour.
2. Place the cassette on a clean and level surface. Hold the dropper vertically and transfer 1 full drop of serum or plasma (approximately 40 μl), then add 2 drops of buffer (approximately 80 μl) to the specimen well of the cassette, and then start the timer. Avoid trapping air bubbles in the specimen well. See illustration below.
3. Wait for the colored line(s) to appear. Read the result at 5 minutes. Do not interpret the result after 10 minutes.
 

For whole blood specimen:
1. Bring the pouch to room temperature before opening it. Remove the test cassette from the sealed pouch and use it as soon as possible.
2. Place the cassette on a clean and level surface.
For Venipuncture Whole Blood specimen:
 Hold the dropper vertically and transfer 1 drop of whole blood (approximately 40 μl) to the specimen well, then add 2 drops of buffer (approximately 80 μl), and start the timer. See illustration below.
For Fingerstick Whole Blood specimen:
 To use a capillary tube: Fill the capillary tube and transfer approximately 40 μl of fingerstick whole blood specimen to the specimen area of test cassette, then add 2 drops of buffer(approximately 80 μl) and start the timer. See illustration below.
3. Wait for the colored line(s) to appear. Read results at 5 minutes. Do not interpret the result after 10 minutes.

 

 

 

 

 

Cat. No.

Product Description

Specimen

Format

Kit Size

Cut-Off

Status

DCT-402

COT Rapid Test Cassette

WB/S/P

Cassette

40 T

10 ng/mL,100 ng/mL*

CE


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