Propoxyphene (PPX) is a narcotic analgesic compound bearing structural similarity to methadone. As an analgesic, propoxyphene can be from 50-75% as potent as oral codeine. Darvocet™, one of the most common brand names for the drug, contains 50-100 mg of propoxyphene napsylate and 325-650 mg of acetaminophen. Peakplasma concentrations of propoxyphene are achieved from 1 to 2 hours post dose. In the case of overdose, propoxyphene blood concentrations can reach significantly higher levels.

In humans, propoxyphene is metabolized by N-demethylation to yield norpropoxyphene. Norpropoxyphene has a longer half-life (30 to 36 hours) than parent propoxyphene (6 to 12 hours).The accumulation of norpropoxyphene seen with repeated doses may be largely responsible for resultant toxicity.

The Propoxyphene contained within the PPX Rapid Test Panel yields a positive result when the PPX concentration exceeds 300ng/ml.

 

【DIRECTIONS FOR USE】

Test device (in closed pouches), samples, and controls should be brought to room temperature (15-30°C) prior to testing. Do not open pouches until ready to perform the assay.

Remove the test device from its protective pouch and label the device with patient’s identification or control label.

FOR SURFACES

1. Wipe with the panel over the surface in which the drugs are expected.

2. Take off the cap of supplied tube;

3. Fill all buffers from the supplied tube of buffer into the protection cover.

4. Insert the Multi Test slowly and carefully into the protection cover with buffer

5. Wait for lines to appear on the membrane and read the results after 5 minutes and do not interpret the result after 10 minutes.

 

FOR SOLIDS

1. Open the tube and put the solid in to the buffer.

2. Close the tube with dropper and cap. Shake it a short time. Wait for 30 sec.

3. Take off the cap of supplied tube;

4. Fill all buffers with dissolved substances into the protection cover.

5. Insert the Multi Test slowly and carefully into the protection cover with buffer.

6. Wait for lines to appear on the membrane and read the results after 5 minutes and do not interpret the result after 10 minutes.