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H-FABP and cTnI Combo Rapid Test Cassette

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H-FABP and cTnI Combo Rapid Test Cassette JusChek Cardiac Marker Rapid Test


¡¾SUMMARY¡¿
FABP is a newly introduced plasma marker of acute myocardial infarction (AMI). The plasma kinetics of FABP (15 kD) closely resemble those of myoglobin in that elevated plasma concentrations are found within 2 hours after AMI and return to normal generally within 18 to 24 hours. But the concentration of FABP in the skeletal muscle is 20 times lower than in cardiac tissue (for myoglobin the same content for cardiac and skeletal tissue), that makes FABP to be more cardiac specific thanmyoglobin. This makes FABP a useful biochemical marker for the early assessment or exclusion of AMI. FABP also appears to be a useful plasma marker for the estimation of myocardial infarct size. FABP is suitable for use as a standard in

immunoassay for early detection of acute myocardial infarction, immunogen for antisera production, mass FABP standard, FABP biochemical and immunochemical studies, tracer for iodination.
Cardiac Troponin I (cTnI) is a protein found in cardiac muscle with a molecular weight of 22.5 kDa. 1 Troponin I is part of a three subunit complex comprising of Troponin T and Troponin C. Along with tropomyosin, this structural complex forms the main component that regulates the calcium sensitive ATPase activity of actomyosin in striated skeletal and cardiac muscle. After cardiac injury occurs, Troponin I is released into the blood 4-6 hours after the onset of pain. The release pattern of cTnI is similar to CK-MB, but while CK-MB levels return to normal after 72 hours, Troponin I remains elevated for 6-10 days, thus providing for a longer window of detection for cardiac injury. The high specificity of cTnI measurements for the identification of myocardial damage has been demonstrated in conditions such as the perioperative period, after marathon runs, and blunt chest trauma.cTnI release has also been documented in cardiac conditions other than acute myocardial infarction (AMI) such as unstable angina, congestive heart failure, and ischemic damage due to coronary artery bypass surgery.Because of its high specificity and sensitivity in the myocardial tissue, Troponin I has recently become the most preferred biomarker for myocardial infarction. The H-FABP/Cardiac Troponin I Combo Rapid Test Cassette (Whole Blood/Serum/Plasma) is a simple test that utilizes a combination of antibody coated particles and capture reagents to qualitatively detect H-FABP and cardiac Troponin I (cTnI) in whole blood, serum or plasma. The minimum detection level is 8ng/mL H-FABP and 0.5 ng/mL Troponin I.

¡¾DIRECTIONS FOR USE¡¿
Allow the test, specimen, buffer and/or controls to reach room temperature (15-30°C) prior to testing.
1. Bring the pouch to room temperature before opening it. Remove the test cassette from the sealed pouch and use it as soon as possible.
2. Place the cassette on a clean and level surface.
For Serum or Plasma specimen:
· Hold the dropper vertically and transfer 2 drops of serum or plasma (approximately 50 µL) to the specimen well, then add 1 drop of buffer (approximately 40 µL), and start the timer. See illustration below.
For Venipuncture Whole Bloodspecimen:
· Hold the dropper vertically and transfer 2 drops of whole blood (approximately 50 µL) to the specimen well, then add 1 drop of buffer (approximately 40 µL), and start the timer. See illustration below.
For Fingerstick Whole Bloodspecimen:
· To use a capillary tube: Fill the capillary tube and transfer approximately 50 µL of fingerstick whole blood specimen to the specimen well of test cassette, then add 1 drop of buffer (approximately 40 µL ) and start the timer.
· To use hanging drops: Allow 2 hanging drops of fingerstick whole blood specimen (approximately 50 µL) to fall into the specimen well of test cassette, then add 1 drop of buffer (approximately 40 µL) and start the timer.
3. Wait for the colored line(s) to appear. Read results at 10 minutes . Do not interpret the result after 20 minutes.

 

Cat. No.

Product Description

Specimen

Format

Kit Size

Cut-Off

Status

CFC-425

H-FABP and cTnI Combo Rapid Test Cassette

WB/S/P

Cassette

25 T

See Insert

CE


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